منابع مشابه
Peripheral metabolic actions of leptin.
The ob gene product, leptin, is produced predominantly in adipose tissue. In ob/ob mice, a mutation in the ob gene prevents normal leptin production and results in a phenotype characterized by obesity and diabetes (Zhang et al. 1994). Daily injections of recombinant leptin to ob/ob mice inhibit food intake and reduce body weight and fat mass (Campfield et al. 1995; Halaas et al. 1995; Pelleymou...
متن کاملThe glucoregulatory actions of leptin
BACKGROUND The hormone leptin is an important regulator of metabolic homeostasis, able to inhibit food intake and increase energy expenditure. Leptin can also independently lower blood glucose levels, particularly in hyperglycemic models of leptin or insulin deficiency. Despite significant efforts and relevance to diabetes, the mechanisms by which leptin acts to regulate blood glucose levels ar...
متن کاملNeuroendocrine regulation and actions of leptin.
The discovery of the adipocyte-produced hormone leptin has greatly changed the field of obesity research and our understanding of energy homeostasis. It is now accepted that leptin is the afferent loop informing the hypothalamus about the state of fat stores, with hypothalamic efferents regulating appetite and energy expenditure. In addition, leptin has a role as a metabolic adaptator in overwe...
متن کاملLeptin, obesity and hypertension: importance of nursing actions
The objective of this systematic review was to retrieve topics of relevance to the implications of leptin in modulating blood pressure and in the genesis, prevention and treatment of hypertension associated with obesity. Considering the hormone as a common link between the two pathological conditions, were identified actions to reduce the leptinemia, proposed and discussed in the literature. It...
متن کاملLeptin resistance and diet-induced obesity: central and peripheral actions of leptin.
Obesity is a chronic disease that represents one of the most serious global health burdens associated to an excess of body fat resulting from an imbalance between energy intake and expenditure, which is regulated by environmental and genetic interactions. The adipose-derived hormone leptin acts via a specific receptor in the brain to regulate energy balance and body weight, although this protei...
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ژورنال
عنوان ژورنال: Brain Research
سال: 2010
ISSN: 0006-8993
DOI: 10.1016/j.brainres.2010.04.011